Abbott: Strange as it may seem, they give ball players nowadays very peculiar names.
Costello: Funny names?
Abbott: Nicknames, nicknames. Now, on the St. Louis team we have Who’s on first, What’s on second, I Don’t Know is on third–
Costello: That’s what I want to find out. I want you to tell me the names of the fellows on the St. Louis team.
Abbott: I’m telling you. Who’s on first, What’s on second, I Don’t Know is on third–
Costello: You know the fellows’ names?
Abbott: Yes.
Costello: Well, then who’s playing first?
Abbott: Yes.
Costello: I mean the fellow’s name on first base.
Abbott: Who.
Costello: The fellow playin’ first base.
Abbott: Who.
Costello: The guy on first base.
Abbott: Who is on first.
Costello: Well, what are you askin’ me for?
Abbott: I’m not asking you–I’m telling you. Who is on first.
Costello: I’m asking you–who’s on first?
Abbott: That’s the man’s name.
Costello: That’s who’s name?
Abbott: Yes.
Costello: When you pay off the first baseman every month, who gets the money?
Abbott: Every dollar of it. And why not, the man’s entitled to it.
Costello: Who is?
Abbott: Yes.
Costello: So who gets it?
Abbott: Why shouldn’t he? Sometimes his wife comes down and collects it.
Costello: Who’s wife?
Abbott: Yes. After all, the man earns it.
Costello: Who does?
Abbott: Absolutely.
Costello: Well, all I’m trying to find out is what’s the guy’s name on first base?
Abbott: Oh, no, no. What is on second base.
Costello: I’m not asking you who’s on second.
Abbott: Who’s on first!
Costello: St. Louis has a good outfield?
Abbott: Oh, absolutely.
Costello: The left fielder’s name?
Abbott: Why.
Costello: I don’t know, I just thought I’d ask.
Abbott: Well, I just thought I’d tell you.
Costello: Then tell me who’s playing left field?
Abbott: Who’s playing first.
Costello: Stay out of the infield! The left fielder’s name?
Abbott: Why.
Costello: Because.
Abbott: Oh, he’s center field.
Costello: Wait a minute. You got a pitcher on this team?
Abbott: Wouldn’t this be a fine team without a pitcher?
Costello: Tell me the pitcher’s name.
Abbott: Tomorrow.
Costello: Now, when the guy at bat bunts the ball–me being a good catcher–I want to throw the guy out at first base, so I pick up the ball and throw it to who?
Abbott: Now, that’s he first thing you’ve said right.
Costello: I DON’T EVEN KNOW WHAT I’M TALKING ABOUT!
Abbott: Don’t get excited. Take it easy.
Costello: I throw the ball to first base, whoever it is grabs the ball, so the guy runs to second. Who picks up the ball and throws it to what. What throws it to I don’t know. I don’t know throws it back to tomorrow–a triple play.
Abbott: Yeah, it could be.
Costello: Another guy gets up and it’s a long ball to center.
Abbott: Because.
Costello: Why? I don’t know. And I don’t care.
Abbott: What was that?
Costello: I said, I DON’T CARE!
Abbott: Oh, that’s our shortstop!
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I would aim for at least 12 weeks if muscle growth is
your primary goal; otherwise, it’s not worth the fee.
For fat loss, general rejuvenation, restoration, and other low-level benefits are
your goal? Nevertheless, these using HGH with a longer-term outlook will have a look at utilizing it for six months and
beyond.
The palms and ft, as well as the jaw area, can turn into noticeably larger.
All of this could lead to critical well being impacts and
stress brought on to important organs. It’s important to be aware that ache in the joints whereas using HGH within the
early stages isn’t a sign that the joints are broken however is a
aspect effect of the repair and progress process that HGH
is stimulating.
Mixture of our experimental outcomes with public transcriptomic and proteomic data revealed a particular position of Ca2+-dependent phospholipid metabolizing enzymes in BR signaling.
Right Here we provide novel insights into the function of calcium stability and lipid-derived second messengers
in plant responses to exogenous BRs and suggest a fancy mannequin integrating BR-mediated metabolic modifications with phospholipid turnover.
The production of steroid medication and hormones
is doubtless one of the greatest examples of the purposes that biotransformations have on an industrial scale
[3, 21].
Anabolic steroids are the most common appearance- and performance-enhancing medication (APEDs).
Roughly 3 to four million individuals within the Usa
use anabolic steroids for nonmedical purposes.
HaCaT cells had been pretreated with or with out 10 μM of each SCA and SCB for 24 h.
Stock solutions of the 2 compounds had been prepared in DMSO immediately earlier
than use and diluted to the ultimate focus in the culture medium.
In some sets of experiments, betamethasone-17-valerate (10 µg/mL) served as a positive management; dimethyl sulfoxide
(DMSO) served as a solvent control. After
the pretreatments, cells have been stimulated with 10
ng/mL TNFα for 1 h to induce the NFκB signaling pathway.
Hypertrophy (size increase) and hyperplasia (increase in cells) are on the core of HGH’s functions.
The body regulates how much these processes occur by controlling how a
lot HGH is launched. Taking exterior synthetic HGH supercharges these
processes, so it is vital that you are not taking extreme
quantities – the body is not going to know when to
stop rising, and this is the place you get your organ and tissue growth complications.
Fortunately, most customers will reasonable HGH dosages sufficient to
avoid these severe side effects completely.
It’s important to know, especially for anabolic steroid customers, that HGH just isn’t an estrogenic or androgenic hormone.
Conversion of canrenone (203) by Colletotrichum lini ST-1 gave two hydroxyl compounds,
15α-hydroxy-canrenone (209, 22%) and 11α,15α-dihydroxy-canrenone (210, 47%) (Figure 27) [80].
Prednisone (169) is a synthetic corticosteroid (prodrug) used for the remedy of autoimmune, inflammatory and kidney
illnesses, among others. Elegans occurred
by hydrogenation of the Δ4(5) and discount of C-20, to provide
the compounds 17α,21-dihydroxy-5α-pregn-1-en-3,11,20-trione (170, 15.6%) and 17α,(20S),21-trihydroxy-5α-pregn-1-en-3,11-dione (171, 6.5%);
whereas as the one biotransformation product, 169 using F.
Lunata (6.2%), was 1,4-pregnadien-17α,(20S),21-trihydroxy-3,11-dione (172) (Figure 21) [88].
Girls will get comparable benefits from HGH to males, however females will normally take a decrease dose.
They will concentrate on improving muscle tone, fat loss, and HGH’s anti-aging effects that
can enhance the looks of skin and hair. Somatotropin is a
human progress hormone used to treat some medical conditions, and
it’s also well-liked with bodybuilders. But it comes with side
effects, and even though it isn’t a steroid and the HGH unwanted aspect effects are mostly
not of the identical nature that we get with anabolic steroids, synthetic HGH for bodybuilding
purposes is a risky selection. The alerts
that HGH sends to the muscles instruct them to develop, however we are able to solely see the true
potential for muscle gains when stacking HGH with anabolic steroids.
With HGH selling cell proliferation, nitrogen retention, and protein synthesis, it’s the proper associate
to AAS in selling the substantial development of
lean muscle[2]. Acquiring hydroxylated derivatives in a selected place
is considered one of the objectives of the steroid business;
for example, 14α-hydroxysteroids are proven to have
anti-inflammatory, contraceptive, and antitumor activities.
(A) Protein constructions of FT (PDB ID 1FT1), GTT-1 (PDB ID 1N4P), and RGGT (PDB ID
1DCE). There are extra leucine-rich repeats (LRRs) and immunoglobulin (Ig)-like domains in the α subunit of
RGGT (α-helices in cyan and β-sheets in red). (B) Superimposition of the
β subunits of FT (cyan), GGT-1 (yellow), and RGGT (magenta) to show the structural homology.
Geranylgeranyl diphosphate (GGPP; indicated by a GGPP analogue in magenta) rotates toward the cysteine in the CaaX peptide (PDB ID 1N4Q) to form the prenylated product (green; PDB
ID 1N4R). (D) Simultaneous binding of GGPP (magenta) and the translocated prenylated product (green) on the
lively site of GGT-1 (PDB ID 1N4S). The
zinc also coordinates with the cysteine residue of CaaX peptides.
(G) Binding place of isoprenoid diphosphate in prenyltransferases,
together with FPP in FT (PDB ID 1FT2) and GGPP in GGT-1 (PDB ID 1N4P) and RGGT (PDB ID 3DST).
At the start of the Granolah arc, this kind was fairly formidable and was only taken out by a surprise hit.
In this form, Goku was able to struggle far more on par with Jiren, despite the very fact that the
shape itself hadn’t been perfected. It was so quick that
nearly all other characters in the series couldn’t even keep up with its actions as Goku dodged all assaults
with little effort. This type was the one which additionally knocked
Kefla out of the tournament with one of many coolest Kamehameha’s
ever. Tremendous Saiyan 2 was an enormous
enchancment upon Super Saiyan and the varied grades that came before it.
In this kind, Goku was much stronger and faster too, as was seen in his incredible struggle towards Majin Vegeta, where both of them
were equal in terms of energy and skill. Though this
form is one that the sequence has largely forgotten about, its power remains to be formidable.
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